Everything You Need to Plan a Knoxville, TN, to Charleston, SC Vacation

It’s easy to plan a Knoxville, TN, to Charleston, SC vacation! Trade the mountains and city life for a relaxing getaway to the charming city of Charleston. Whether you choose to lounge on the beach and soak up the sun or explore the city’s rich history and architecture, you’re sure to leave refreshed with long-lasting memories. 

Request a free copy of our digital Vacation Guide to unlock our favorite things to do in the Holy City before you even arrive! You’ll get access to our top recommended restaurants, bars, activities, and more to ensure you enjoy every second of your vacation.

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Your Guide to a Knoxville, TN, to Charleston, SC, Vacation 


There are endless benefits to traveling to Charleston! Not only can a change of scenery be just what you need to clear your mind and feel refreshed, but Charleston is one of the best destinations to do just that. Step away from the city for a while to enjoy slow-paced days of lounging on the beach, spending time outdoors, and recharging.  

Map Your Route 

While there are shorter road trips from Knoxville, Charleston is more than worth the trip! In under 6 hours, via I-40 E and I-26 E, you’ll be dipping your toes in the glistening ocean water.  

Stops Along the Way 

While driving along I-40 E, you’ll run into Asheville, NC, just under two hours into your journey. Asheville has a variety of offerings and makes for an excellent stop along the way! You can find everything from nature and recreation opportunities to a thriving culinary scene, and, of course, the infamous Biltmore House. Asheville is a wonderful city to spend an afternoon before hopping in the car and continuing on to Charleston! 

The Perfect Packing List 

You already know the essentials when packing for a beach vacation. It’s easy to remember swimsuits, beach towels, and sunglasses, but what else? Here are a few extras that you won’t want to leave off your packing list! 

  • Beach games (volleyball or spikeball for adults and sandcastle tools for the little ones) 
  • Appropriate clothing to endure the Charleston humidity 
  • High SPF sunscreen 
  • Walking shoes to keep you exploring and experiencing longer 
  • The book you’ve been wanting to read for months 
  • Reusable water bottles to lower risk for plastic pollution 

There’s No Better Place to Stay Than Charleston Coast Vacations  

Allow Charleston Coast Vacations to take care of every need during your time in Charleston. Take a look at our incredible beach homes on Folly BeachSullivan’s Island, and Isle of Palms to find your perfect villa. We want you to feel right at home while you’re visiting the Holy City. After all, that’s what southern hospitality is all about! You’ll find something just right for any occasion, including romantic getaways, family vacations, and even group trips! Book your stay with us today to start planning your Knoxville, TN, to Charleston, SC, vacation! We can’t wait to host your stay in the Lowcountry. 

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